Located on 115 acres in the Greenspring Valley, Maryvale's campus with sprawling woods, nature trails, streams, and waterfalls is an idyllic setting for a school. The centerpiece of the picturesque campus is Wickliffe Castle, modeled after Warwick Castle in Warwickshire, England. Built in 1916, the Tudor-style building was the home of Dr. and Mrs. Walter F. Wickes and their five children.

Today, the castle stands as a reminder of the school's rich history from a private home to a boarding school and now as a college-preparatory institution. The Castle houses a chapel, the library, administrative offices and classrooms. The Great Hall is a gathering place for music, lectures, holiday events, dances, and even wedding receptions for many Maryvale alumnae.

Considered one of the largest private residences in the area at the time, Wickcliffe has 65 rooms. The largest room, the Great Hall, was often the location for lavish entertainment. In 1945, after the death of his wife, Dr. Wickes sold the estate, including many of its furnishings, to the Sisters of Notre Dame de Namur who established it as Maryvale Trinity College Preparatory School, a girls' boarding school.

The Middle School building stands adjacent to the Castle, overlooking the woods. On the other side of the Castle is the former Carriage House, now used as classrooms.

The Erinn McCarthy Humanities Hall, the newest building on campus, features a state-of-the-art theater, a Mac lab, additional classrooms, a technology resource center and choral and instrumental music rooms with practice suites. 

Recent upgrades include an artificial turf field, a regulation track with field event facilities, practice fields and a new softball field.